Saints will face Hull FC in the Ladbrokes Challenge Cup Quarter-final on Sunday June 3 (3:30pm).
The ties start with Huddersfield Giants v Catalans Dragons on Sky Sports on Thursday May 31 (7:35pm).
Betfred Super League Champions Leeds Rhinos will then go head-to-head with the only remaining Betfred Championship side, Leigh Centurions in the second fixture to be shown live on Sky Sports on Friday June 1 (7:35pm).
BBC Sport will broadcast two games over the weekend starting with Warrington Wolves v Wigan Warriors on Saturday June 2 (2:30pm) and followed by our match up with current Ladbrokes Challenge Cup holders, Hull FC, on Sunday June 3 (3:30pm).
The Ladbrokes Challenge Cup semi-final draw will be conducted live on BBC Sport at the Totally Wicked Stadium following the conclusion of the St Helens v Hull FC fixture.
Confirmed Ladbrokes Challenge Cup Quarter-final schedule:
Thursday, May 31 – Huddersfield Giants v Catalans Dragons (7.35pm, Sky Sports)
Friday, June 1 – Leeds Rhinos v Leigh Centurions (7.35pm, Sky Sports)
Saturday, June 2 – Warrington Wolves v Wigan Warriors (2.30pm, BBC One)
Sunday, June 3 – St Helens v Hull FC (3.30pm, BBC Two)
Ticket details will be released shortly.